Cutaneous T-cell lymphoma and cutaneous graft-versus-host disease - Two indications for photopheresis in dermatology

Dermatologists are frequently involved in the management of cutaneous T-cel l lymphoma (CTCL) and graft-versus-host disease (GVHD). The similarities of these two entities are reviewed in the context of clinical and histologic findings, pathogenesis, and therapy. Photopheresis therapy (extracorporeal photochemotherapy) is used in the treatment of both entities, and the mecha nisms underlying the responses represent yet another striking similarity of these two crippling dermatologic diseases.