Pharmacological treatments of postprandial hyperglycemia

Every diabetes treatment contributes to the control of postprandial blood g lucose, yet some agents more specifically target this goal. Alpha-glucosidase inhibitors, led by acarbose, mainly address postprandial glucose control. These agents inhibit intestinal disaccharidases through a competitive effect and can be used either as the sole treatment or in combi nation with other antidiabetic drugs. Other agents improve insulin secretion kinetics. This is the case for repag linide et nateglinide, which are efficient in controlling postprandial bloo d glucose, and to a lesser degree, fasting blood glucose. These agents shor tly and quickly stimulate insulin secretion and should be available soon. I n oral therapy secondary failures, trials are currently being conducted to clarify the role of fast-acting insulin analogs, as monotherapy or in combi nation. Finally, insulin sensitizing agents are being investigated as a way to impr ove postprandial glucose efflux by potentiating insulin effects. The optimal strategy for the use of these different therapeutic agents rema ins to be established, as well as their long-term effects on diabetic compl ications.