Many of the new technologies currently transforming the way in which pharma
ceutical R&D is performed consume far more cash and resources than traditio
nal 'wet' bench science. They also carry a high degree of risk. It is there
fore crucial that the industry finds systematic methods of evaluating them
effectively. This article examines the strategic perspective and internal p
rocesses companies should adopt to ensure that they spend their money wisel
y. It also outlines a three-tier approach, based on decision analysis techn
iques, for objectively assessing specific technology options - including di
scovery technologies, which are notoriously difficult to evaluate - to buil
d a technology portfolio.