Hormonal modulation of GM-CSF receptor alpha-chain in in vitro models of endometrial cancer

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine tha t stimulates the proliferation and differentiation of bone marrow progenito rs. Moreover, the presence and activity of GM-CSF and its receptor (GM-CSF- r) has been documented on tissues and cell lines of a non-hemopoietic origi n. In this paper we studied the expression and putative role of GM-CSF and GM-CSF-r in endometrial cancer The modulation of GM-CSF-r alpha-chain upon progesterone treatment suggests a role for GM-CSF and its receptor in the p athogenesis and development of endometrial cancer.