The timing of arm-trunk coordination is deficient and vision-dependent in Parkinson's patients during reaching movements

The role of the basal ganglia in the coordination of different body segment s and utilization of motor synergies was investigated by analyzing reaching movements to remembered three-dimensional (3D) targets in patients with Pa rkinson's disease (PD). Arm movements were produced alone or in combination with a forward bending of the trunk, with or without visual feedback. Move ments in PD patients were more temporally segmented, as evidenced by irregu lar changes in tangential velocity profiles. In addition, the relative timi ng in the onsets and offsets of fingertip and trunk motions were substantia lly different in PD patients than in control subjects. While the control su bjects synchronized both onsets and offsets, the PD patients had large mean intervals between the onsets and offsets of the fingertip and trunk motion s. Moreover, PD patients showed substantially larger trial-to-trial variabi lity in these intervals. The degree of synchronization in PD patients gradu ally increased during the movement under the influence of visual feedback. The mean and variability of the intersegmental intervals decreased as the f ingertip approached the target, This improvement in timing occurred even th ough the separate variability in the timing of arm and trunk motions was no t reduced by vision. In combined movements, even without vision, the PD pat ients were able to achieve normal accuracy, suggesting they were able to us e the same movement synergies as normals to control the multiple degrees of freedom involved in the movements and to compensate for the added trunk mo vement. However, they were unable to reemit these synergies in the stereoty ped manner characteristic of healthy subjects. These results suggest that t he basal ganglia are involved in the temporal coordination of movement of d ifferent body segments and that related timing abnormalities may be partly compensated by vision. Abnormal intersegmental timing may be a highly sensi tive indicator of a deficient ability to assemble complex movements in pati ents with basal-ganglia dysfunction. This abnormality may be apparent even when the overall movement goal of reaching a target is preserved and normal movement synergies appear to be largely intact.