M. Wu et al., An integrated deletion and physical map encompassing l71Rl, a chromosome 7locus required for peri-implantation survival in the mouse, GENOMICS, 67(2), 2000, pp. 228-231
l71Rl, a locus that maps just proximal to the pink-eyed dilution (p) locus
in mouse chromosome 7, was initially identified as being required for early
post-implantation survival. We define further the null phenotype of l71Rl
as peri-implantation lethal, with homozygous mutant embryos degenerating be
tween embryonic day 4.5 (E4.5) and E5.5. We constructed an integrated delet
ion/physical map covering a 1.82-Mb chromosomal segment extending proximall
y from p. This map defines the minimum critical interval for l71Rl as an 80
- to 300-kb region. This sequence-ready deletion/physical map should enable
the cloning and characterization of the l71Rl gene(s). (C) 2000 Academic P
ress.