Evaluation of a model of the cochlear neural membrane. II: Comparison of model and physiological measures of membrane properties measured in responseto intrameatal electrical stimulation

Authors
Citation
La. Cartee, Evaluation of a model of the cochlear neural membrane. II: Comparison of model and physiological measures of membrane properties measured in responseto intrameatal electrical stimulation, HEARING RES, 146(1-2), 2000, pp. 153-166
Citations number
26
Categorie Soggetti
da verificare
Journal title
HEARING RESEARCH
ISSN journal
03785955 → ACNP
Volume
146
Issue
1-2
Year of publication
2000
Pages
153 - 166
Database
ISI
SICI code
0378-5955(200008)146:1-2<153:EOAMOT>2.0.ZU;2-S
Abstract
This study examines existing equation sets describing neural membrane ionic currents, such as the Hodgkin-Huxley (1952) equations, used to define the membrane currents in a numerical model of the auditory neuron and determine s their adequacy for modeling the summation and refraction properties of au ditory neurons in response to electrical stimulation. Specifically, the sum mation and refraction time constants of each equation set are compared to p hysiological measures of these time constants. Since previous studies have shown the cell body and peripheral process of the auditory neuron may influ ence the measurement of neural time constants, the physiological time const ants used for comparison are those which were recorded using intrameatal el ectrical stimulation. The intrameatal electrode should stimulate the neuron in an area where the axon has a uniform geometry. Accordingly, the neural model used to duplicate this experiment was also of uniform geometry. Of th e membrane equation sets evaluated, none was clearly superior for modeling both the refraction and summation properties of the auditory neuron, though some equation sets were capable of accurately modeling either the refracti on or the summation properties, provided operating temperatures were adjust ed to provide appropriate kinetics. (C) 2000 Elsevier Science B.V. All righ ts reserved.