Cases of 445 adult Japanese autopsies of the Tokyo Metropolitan Medical Exa
miner's Office were used in this study. They were either negative for all h
epatitis virus-related markers examined or had little or no histopathologic
al hepatic changes. The maximum liver weight was observed in the fifth deca
de in both sexes, and after the fifth decade the liver weight decreased mar
kedly with increasing age. The sexual difference in the liver weight was mo
st predominant in the third to fifth decades, but the sexual difference was
not marked in the older age groups. The highest liver weight to body weigh
t ratio was observed in the fifth decade of both sexes, and a total decadal
pattern of the ratio was similar to a parabola. An interesting finding was
that the male liver weights in the third to fifth decades considerably inc
reased in recent years, but the female liver weights in the third decade we
re almost the same despite the difference in investigation period. We sugge
st the data of this study may be a standard for Japanese people. (C) 2000 E
lsevier Science Ireland Ltd. All rights reserved.