A long-term survival case of multiple hepatocellular carcinoma with metachronous lymph node metastasis

A long-term survival case of multiple hepatocellular carcinoma (HCC) with m etachronous metastasis to a lymph node is reported. The patient, a 66-year- old woman, had two primary HCC nodules, one each in the left and right hepa tic lobes, which were resected. She developed a lymph node lesion and a sec ondary HCC 45 and 62 months after the first operation, respectively, She ha s been well for the 7 years since the first operation despite undergoing he patic resection for HCC twice as well as lymph node resection. Clonal analy sis, based on the methylation pattern of the X chromosome-linked androgen r eceptor gene, suggested that the two primary tumors were multicentric and t hat the lymph node lesion had arisen by metastasis from the primary tumor i n the right hepatic lobe. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.