Haptoglobin phenotypes in HIV-1-seropositive patients in Ghana: Decreased risk for Hp0 individuals

Authors
Quaye, IKE Ekuban, FA Brandful, JAM Gyan, BA Akanmori, BD Ankrah, NA
Citation
Ike. Quaye et al., Haptoglobin phenotypes in HIV-1-seropositive patients in Ghana: Decreased risk for Hp0 individuals, HUMAN HERED, 50(6), 2000, pp. 382-383
Citations number
16
Categorie Soggetti
Molecular Biology & Genetics
Journal title
HUMAN HEREDITY
ISSN journal
00015652 → ACNP
Volume
50
Issue
6
Year of publication
2000
Pages
382 - 383
Database
ISI
SICI code
0001-5652(200011/12)50:6<382:HPIHPI>2.0.ZU;2-M
Abstract
Plasma haptoglobin phenotypes were determined by polyacrylamide gel electro phoresis, followed by benzidine staining for 58 HIV-1 seropositive Ghanaian s and 79 randomly selected age-matched controls. Hp0 was present in only 14 % of HIV-1 seropositive individuals compared with more than 40% of the cont rols. The Hp0 individuals showed a highly significant reduced risk for HIV- 1 infection (OR = 0.21, 95% CI = 0.09-0.51, p = 0.0002). Hp0 may have a pro tective effect in HIV-1 infection. Copyright (C) 2000 S. Karger AG, Basel.