This paper presents a methodology to solve the Just-in-Time (JIT) sequencin
g problem for multiple product scenarios when set-ups between products are
required. Problems of this type are combinatorial, and complete enumeration
of all possible solutions is computationally prohibitive. Therefore, Genet
ic Algorithms are often employed to rnd desirable, although not necessarily
optimal, solutions. This research, through experimentation, shows that Gen
etic Algorithms provide formidable solutions to the multi-product JIT seque
ncing problem with set-ups. The results also compare favourably to those fo
und using the search techniques of Tabu Search and Simulated Annealing.