The effect of supraphysiological doses of anabolic androgenic steroids on collagen metabolism

We examined the effect of supraphysiological doses of anabolic androgenic s teroids (AAS) on collagen metabolism and whether the changes reflect the al terations in muscle, bone, and tendon collagen metabolism, possibly in a ti ssue-specific manner. Serum carboxyterminal propeptide of type I procollage n (PICP), carboxyterminal telopeptide of type I collagen (ICTP), aminotermi nal propeptide of type III procollagen (PIIINP), urine hydroxylysylpyridino line (HP), and lysylpyridinoline (LP) as well as urine creatinine were dete rmined from 17 men abusing AAS. Measurements were made twice during the int ake of AAS and twice during the subsequent withdrawal period. When the volu nteers were on steroids, their serum PIIINP concentrations and urine HP/LP ratio were significantly higher and their serum ICTP concentrations were si gnificantly lower than during the withdrawal period (p<0.05). Serum PIIINP correlated with total cumulative doses of injectable intramuscular steroids , and serum ICTP correlated with the duration of the steroid intake period (p<0.05). The results suggest that high doses of AAS decrease the degradati on and seem to increase the synthesis of type I collagen. Furthermore, high doses of AAS are suggested to enhance soft tissue collagen metabolism on t he basis of increased type III collagen synthesis and elevated HP/LP ratio during the steroid administration period. Although the tissue-specific turn over of collagen of soft connective tissues remains unknown, the turnover o f bone collagen seems not to change following the use of high doses of AAS, at least within the time interval of the present study.