SYNTHESIS AND ANTITUMOR-ACTIVITY OF 3-ARYLISOQUINOLINE DERIVATIVES

Authors
CHO WJ YOO SJ PARK MJ CHUNG BH LEE CO
Citation
Wj. Cho et al., SYNTHESIS AND ANTITUMOR-ACTIVITY OF 3-ARYLISOQUINOLINE DERIVATIVES, Archives of pharmacal research, 20(3), 1997, pp. 264-268
Citations number
8
Categorie Soggetti
Biology
Journal title
Archives of pharmacal research → ACNP
ISSN journal
02536269
Volume
20
Issue
3
Year of publication
1997
Pages
264 - 268
Database
ISI
SICI code
0253-6269(1997)20:3<264:SAAO3D>2.0.ZU;2-L
Abstract
In order to study the structure-activity relationship of ethylenedioxy -2-vinylphenyl)isoquinoline-1(2H)-one (2), which has exhibited signifi cant antitumor activity, chemical modifications of 2 were performed to yield the corresponding products (3-7). Further systematic uses of an efficient procedure for the synthesis of 3-arylisoquinoline derivativ es produced the substituted compounds (9a-9g), which were tested for i n vitro antitumor activity against five different human cancer cell li nes.