AN EFFICIENT SYNTHESIS OF 3-(E)-HYDROXYPROPENYL CEPHEM DERIVATIVES, KEY INTERMEDIATES FOR 3-(E)-AMMONIOPROPENYLCEPHALOSPORIN ANTIBIOTICS

Citation
Ys. Lee et al., AN EFFICIENT SYNTHESIS OF 3-(E)-HYDROXYPROPENYL CEPHEM DERIVATIVES, KEY INTERMEDIATES FOR 3-(E)-AMMONIOPROPENYLCEPHALOSPORIN ANTIBIOTICS, Archives of pharmacal research, 20(3), 1997, pp. 288-290
Citations number
10
Categorie Soggetti
Biology
ISSN journal
02536269
Volume
20
Issue
3
Year of publication
1997
Pages
288 - 290
Database
ISI
SICI code
0253-6269(1997)20:3<288:AESO3C>2.0.ZU;2-2
Abstract
An efficient synthesis of 3-(E)-hydroxy- and 3-(E)-acetoxypropenylceph em derivatives, key intermediates for the synthesis of 3-(E)-propenylc ephalosporins was achieved via Stille coupling reaction of 3-trifloxyc ephem with 3-(E)-tributylstannylallylic alcohol.