P. Stead et al., Discovery of novel ansamycins possessing potent inhibitory activity in a cell-based oncostatin M signalling assay, J ANTIBIOT, 53(7), 2000, pp. 657-663
We describe the isolation and characterisation of novel non-benzoquinone an
samycin metabolites related to geldanamycin from a culture of Streptomyces
sp. S6699. The compounds possess potent inhibitory activity in a cell-based
assay measuring inhibition of oncostatin M signalling in a reporter cell l
ine utilising a secreted placental alkaline phosphatase (sPAP) readout. In
this paper we report the isolation and structure elucidation of the compoun
ds and describe some of their biological properties.