SYNTHESIS OF NOVEL COUMARIN-3-CARBOXYLIC ACID-DERIVATIVES AS CHEMICAL-DETECTORS OF HYDROXYL RADICALS IN BIOLOGICAL-SYSTEMS

Authors
BEZUGLOV VV BIAGLOW JE MANEVICH Y
Citation
Vv. Bezuglov et al., SYNTHESIS OF NOVEL COUMARIN-3-CARBOXYLIC ACID-DERIVATIVES AS CHEMICAL-DETECTORS OF HYDROXYL RADICALS IN BIOLOGICAL-SYSTEMS, Bioorganiceskaa himia, 23(4), 1997, pp. 310-313
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Bioorganiceskaa himia → ACNP
ISSN journal
01323423
Volume
23
Issue
4
Year of publication
1997
Pages
310 - 313
Database
ISI
SICI code
0132-3423(1997)23:4<310:SONCAA>2.0.ZU;2-E
Abstract
Synthesis of new coumarin-3-carboxylic acid amides and esters with pho sphatidylethanolamine, cetylamine, cholesterol, and acetoxymethanol wa s described. When interacting with hydroxyl radicals generated by chem ical methods or by gamma-irradiation, these compounds formed intensely fluorescent hydroxylation products and can be used for a site-specifi c detection of hydroxyl radicals in biological systems.