Plasma lipid and blood glucose levels in patients with destructive periodontal disease

Hyperlipidaemia and hyperglycaemia are major risk factors for cardiovascula r disease. In recent years, some evidence has been presented that periodont al disease is associated with an increased risk of cardiovascular disease. To further elucidate this association, we have studied standard blood chemi stry variables known as risk markers for cardiovascular disease in periodon tally diseased and healthy subjects. We have measured levels of plasma lipi ds and fasting blood glucose in 39 subjects with moderate periodontal disea se (age 50-60 years) and compared the results with those obtained in 40 age - and sex-matched controls. Both groups were systemically healthy according to their medical history. Total cholesterol, low density lipoprotein chole sterol and triglycerides were significantly higher in periodontally disease d subjects by about 8% (p<0.03), 13% (p<0.003) and 39% (p<0.001), respectiv ely, when compared to controls. Although subjects with diabetes were exclud ed from the study, we found significantly higher blood glucose levels in th e patient than in the control group (85+/-25 versus 73+/-17 mg/dl; p<0.02). There was also a significantly higher frequency of pathological plasma lip id profiles in the patient than in the control group. The results indicate that hyperlipaemia and pre-diabetes may be associated with periodontal dise ase in systemically healthy subjects. These data do not allow us to decide, whether periodontal disease causes an increase in hyperlipaemia and in a p rediabetic state or whether periodontal disease and cardiovascular disease share hyperlipidaemia and the prediabetic state as common risk factors.