Nodular hidradenocarcinoma with prominent squamous differentiation: case report and immunohistochemical study

We report the case of a 24-year-old woman with nodular hidradenocarcinoma o n the scalp, While histopathology of the tumor showed a circumscribed, lobu lated intradermal mass with prominent squamous differentiation, the immunoh istochemical study with antibodies to cytokeratins, CAM 5.2 and 19, epithel ial membrane antigen, carcinoembryonic antigen, S-100 protein and p53 all d emonstrated positivity. These findings confirmed that the tumor was of eccr ine sweat gland origin and it was thought to be a nodular hidradenocarcinom a differentiating toward the eccrine duct and/or secretory portions. She wa s treated with a wide local excision and no recurrence was observed 18 mont hs after excision.