Citation
Sw. Rhee et Mj. Tanga, Synthesis of tritium labelled 4P-PDOT, a selective melatonin receptor antagonist, J LABEL C R, 43(9), 2000, pp. 925-932
Citations number
9
Categorie Soggetti
Chemistry & Analysis","Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
ISSN journal
03624803
→ ACNP
Volume
43
Issue
9
Year of publication
2000
Pages
925 - 932
Database
ISI
SICI code
0362-4803(200008)43:9<925:SOTL4A>2.0.ZU;2-L
Abstract
A selective MT2 melatonin receptor antagonist, 4-phenyl-2-propionamidotetra
lin (4P-PDOT), was prepared as a tritium-labelled compound with high specif
ic activity and radiochemical purity. Catalytic hydrogenation of a unique v
inyl bromo precursor 10 was used to introduce the tritium.