FAMILIAL SPASTIC PARAPLEGIA - EVIDENCE FOR A 4TH LOCUS

Autosomal dominant familial spastic paraparesis (AD-FSP) is a genetica lly heterogeneous disorder of the central nervous system characterized by a progressive spasticity of the legs. One gene causing AD-FSP (FSP 1) has recently been mapped to chromosome 14q, another gene (FSP2) to chromosome 2p, and a third gene (FSP3) to chromosome 15q. We now repor t a large Dutch family with AD-FSP without linkage to any of these chr omosomes, providing evidence for a fourth locus (FSP4). (C) 1997 Elsev ier Science B.V.