Subcellular distribution patterns of twenty four elements in the human liver samples studied by molecular activation analysis

Molecular activation analysis based on biological separation techniques com bined with instrumental neutron activation analysis (INAA) was applied to s tudy the distribution patterns of 24 elements, including essential and unkn own trace elements in the liver organelles. Concentrations of As, Au, Co, I , Mg, Mo, Sb, Sc, Se and Th were found to be the highest in nuclei and mito chondria, while those of Br, Cl, Cs, Cu, K, Na, Rb and V were found to be i n cytosol. Concentrations of Al, As, Au, Ba, Fe, I, Sb were found to be the lowest in cytosol. The element As was mainly present in the nuclear fracti on, where its concentration was two to four times higher than that in other fractions. Ca and Fe were highly enriched in the microsomal fraction.