Pulsed-dye laser versus conventional therapy in the treatment of warts: A prospective randomized trial

Background: The clinical management of verrucae vulgaris is often challengi ng, and no ideal treatment currently exists. Early studies suggested that p ulsed-dye laser (PDL) therapy might be highly effective in the treatment of verrucae, although more recent reports have been less optimistic. Previous studies have been retrospective or have consisted of a series of patients treated with PDL alone. Objective: Our objective was to prospectively evaluate the efficacy of PDL therapy versus conventional therapy with liquid nitrogen cryotherapy or can tharidin in the treatment of warts. Methods: Forty healthy adult patients with verrucae were randomized to rece ive either PDL (585 nm) therapy or conventional therapy All enrollees also performed home therapy Patients were eligible for up to 4 treatment session s at 1-month intenials. Warts were individually counted and measured at the time of each treatment session. Complete response was defined as complete absence of verrucae with the presence of dermatoglyphics, and pal tial resp onse was defined as a 50% or greater reduction in wart size. Results: A total of 194 warts were evaluated by the conclusion of the study . Complete response was noted in an average of 70% of the warts treated wit h conventional therapy and in 66% of chose in the PDL group; this was stati stically insignificant. Partial response was observed in an average of 82% of the warts in patients treated with conventional therapy and 87% in the P DL group. Verruca vulgaris responded more readily than verruca plantaris in both treatment groups. The mean number of treatments to achieve success wa s similar in both groups. Conclusion: The PDL is an efficacious form of therapy for verrucae, as is c onventional therapy PDL therapy should be considered among the better estab lished approaches in the treatment of warts, although data from this trial suggest that this approach is probably not superior.