Clinical efficacy of trandolapril in patients with hypertensive disease (essential hypertension)

Aim. To study antihypertensive efficacy and tolerability of angiotensin con verting enzyme inhibitor trandolapril. Material. Patients with stage I-II ( WHO classification) essential hypertension (n=34, 18 men and 16 women, mean age 49,6+/-8,78 years). Control group comprised 20 healthy persons. Method s. Echocardiography and 24-hour blood pressure monitoring were carried out before and in 4 weeks of treatment. The dose of trandolapril depended on in itial blood pressure and was 0,5-4 mg o.d. Results. Treatment with trandola pril was associated with significant reduction of total peripheral vascular resistance by 16,8%, and lowering of mean 24-hour blood pressure by 10,2%. According to results of blood pressure monitoring high hypotensive efficac y of trandolapril was sustained throughout 24 hours. Daytime blood pressure was lowered by 10,9% (systolic) and 9,4% (diastolic), nighttime blood pres sure - by 7,3% (systolic) and 8,8% (diastolic) (p<0,05). Portion of measure ments with figures above normal also substantially decreased. Moreover tran dolapril affected favorably parameters of circadian blood pressure rhythm. Efficacy of the drug was increased by concomitant use of diuretics and calc ium antagonists from phenylalkylamine group. Conclusion. In patients with e ssential hypertension trandolapril exhibited high efficacy and good tolerab ility.