Inheritance of augmented activity of Ca2+-dependent K+-channels in second generation hybrid rats (SHRxWKY)

The aim of our study was to determine if the increased activity of Ca2+-dep endent K+-channels contribute to hypertensive phenotype in SHRxWKY F-2-rats . We have shown that blood pressure level correlates with Ca2+-dependent K-channels activity in erythrocytes of F-2 rats, but correlation coefficient s were sex related (r = 0,37, p<0,05, for male F-2' r = -0,44, p<0,05, for female F-2). We did not find statistical differences in Ca2+-dependent K+-c hannels activity between males and females in erythrocytes from rats of bot h lines. We suppose that sex chromosomes are involved in the transmittance of this trait in F-2-rats.