Poor prognosis acute myelogenous leukemia: 1 - response to treatment with high dose cytarabine/mitoxantrone/ethyol @ (Amifostine)

Twenty patients with poor prognosis AML and four patients in the blastic ph ase of a myeloproliferative disorder were treated with two 'pulses' of ther apy each consisting of two doses of high dose araC (separated by 12 h) foll owed by a single dose of mitoxantrone. The pulses were separated by 96 h. A mifostine was then administered tiw. The median age of the population was 6 8 years with 88% of patients having had either a prior MDS, MPD or toxic ex posure. The acute leukemia of 58% of patients either entered a CR or revert ed to preleukemic state. For patients under 70 years of age, treatment prod uced 62% CRs with a leukemia free decision marrow in 77%. For patients over 70 years the CR rate was 27% with 36% of patients having a leukemia free d ecision marrow. (C) 2000 Elsevier Science Ltd. All rights reserved.