P-31 NMR INEPT spectroscopy: a powerful tool for structural analysis of phosphitylated carbohydrates

The application of the refocused-decoupled INEPT pulse sequence in P-31 NMR spectroscopy allows, in conjunction with computer simulations, a straightf orward editing of the spectra. Experiments were performed on phosphite deri vatives of selected mono- and disaccharide model compounds. Structural inve stigations point towards the existence of homonuclear P-31-(31)p couplings through O-P coordination versus coupling through the ring chains, the origi n of which is being attributed to donor-acceptor chelating interactions bet ween phosphorus and oxygen atoms in spatially closely related dioxaphosphol ane rings. Copyright (C) 2000 John Wiley & Sons, Ltd.