Spline-based estimation of cure rates: An application to the analysis of breast cancer data

Authors
Myasnikova, EM Asselain, B Yakovlev, AY
Citation
Em. Myasnikova et al., Spline-based estimation of cure rates: An application to the analysis of breast cancer data, MATH COMP M, 32(1-2), 2000, pp. 217-228
Citations number
31
Categorie Soggetti
Engineering Mathematics
Journal title
MATHEMATICAL AND COMPUTER MODELLING
ISSN journal
08957177 → ACNP
Volume
32
Issue
1-2
Year of publication
2000
Pages
217 - 228
Database
ISI
SICI code
0895-7177(200007)32:1-2<217:SEOCRA>2.0.ZU;2-U
Abstract
This paper considers the utility of spline approximations of the hazard fun ction for estimation of cure rates from survival data. With this approach, it is possible to assess dissimilar effects of various covariates on the pr obability of tumor cure and on the timing of the endpoint (death, tumor rec urrence, etc.) under study. The usefulness of the approach is illustrated w ith an application to data on survival of patients treated for breast cance r. (C) 2000 Elsevier Science Ltd. All rights reserved.