Protection against snake venom-induced neuronal injury by the new hypothalamic neurohormone

The action of PRP is characterized by the pronounced activation of the back ground activity (BA) of the brain spinal cord, and the degree of the activi ty depends on BA initial level. The typical peculiarity of Vipera raddei ve nom influence is the initial increase in frequency of BA with subsequent de pression. A preliminary injection of PRP has a protective effect at subsequ ent influence of venom. In animals with hemisection the PRP increases the d ecreased activity of neurons on injury side. Taking into consideration the protective peculiarities of PRP in the relationship to snake venom and the possibility of the latter to stabilize and prolong the action of drugs (in the case of PRP) combined with them, it is supposed that the mentioned use of the combination in clinical practice will be perspective. The data obtai ned testify the PRP to be a neuroprotector against many toxic compounds for med in organism (glutamate, ceramid, beta-amyloid neurotoxisity, etc.). Inv estigations in this aspect are still in the process.