Recurrent isolated ptosis in presumed ophthalmoplegic migraine of childhood

Purpose: To report a rare case of isolated, recurrent unilateral eyelid pto sis as the sole manifestation of ophthalmoplegic migraine in a healthy youn g girl. Design: Single observational case report with review of the literature. Testing: Serologic evaluation, electromyographic, nerve conduction and Tens ilon testing, magnetic resonance and computerized tomographic imaging, and magnetic resonance angiography were performed. Main Outcome Measures: Four-year descriptive history of recurrent eyelid pt osis, Results: Between 1994 and 1998, seven discrete episodes or right upper eyel id ptosis without ophthalmoplegia or pupil abnormality occurred. On each oc casion, spontaneous resolution occurred over a period of 6 to 10 weeks. Ext ensive clinical and laboratory evaluation, including testing for myasthenia gravis and magnetic resonance cerebral angiography, was unremarkable. Conclusions: Recurrent isolated ptosis is a rare manifestation of presumed ophthalmoplegic migraine in childhood. As far as we are aware, this has not been previously reported. Ophthalmology 2000;107:1476-1478 (C) 2000 by the American Academy of Ophthalmology.