Iris lymphoma in a pediatric cardiac transplant recipient - Clinicopathologic findings

Purpose: lymphoproliferative disorder, Design: Methods: To report the unusual presentation of a confirmed iris lym phoma in the setting of posttransplant Case report with clinicopathologic f indings. Methods: The medical record was reviewed for clinical manifestations, cours e of disease, and pathologic and radiologic findings. Results: A 4-year-old girl who had undergone a cardiac transplant at 3 mont hs of age was found to have unilateral iris lesions associated with granulo matous uveitis. Her condition was unresponsive to local and systemic steroi ds, so she underwent an iris biopsy that was found to contain a B cell-deri ved monoclonal lymphoproliferation. Treatment with systemic chemotherapy in cluding cyclophosphamide and prednisone resulted in a transient, partial re sponse. Localized radiotherapy induced total regression of the iris lesions . She continues to be observed and has been free of recurrence or metastasi s for the past 12 months. Conclusions: Because of the increased use of organ transplantation, eye car e specialists should consider the diagnosis of intraocular lymphoma when co nfronted with uveitis-like syndrome unresponsive to topical steroid therapy , Although there are numerous treatment options for intraocular lymphoma, r adiation therapy was found to be effective in the treatment of this case. O phthalmology 2000; 107:1479-1482 (C) 2000 by the American Academy of Ophtha lmology.