A concise asymmetric synthesis of a beta-lactam-based cholesterol absorption inhibitor

Authors
Wu, GG
Citation
Gg. Wu, A concise asymmetric synthesis of a beta-lactam-based cholesterol absorption inhibitor, ORG PROC R, 4(4), 2000, pp. 298-300
Citations number
13
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC PROCESS RESEARCH & DEVELOPMENT
ISSN journal
10836160 → ACNP
Volume
4
Issue
4
Year of publication
2000
Pages
298 - 300
Database
ISI
SICI code
1083-6160(200007/08)4:4<298:ACASOA>2.0.ZU;2-2
Abstract
A concise, four-step, asymmetric synthesis of a beta-lactam-based cholester ol absorption inhibitor, Sch 57939, was developed, The discovery of a one-s tep enantio- and diastereoselective synthesis of a trans-beta-lactam provid ed easy access to the desired three chiral centers. A novel zinc phenoxide- promoted ether synthesis was reported for the completion of the side chain.