Tubulointerstitial nephritis following high-dose ifosfamide in three breast cancer patients

We report three cases of women with breast cancer who developed renal impai rment following treatment with high-dose ifosfamide. All the women underwen t renal biopsy, which demonstrated severe interstitial damage with tubular changes by light and electron microscopy. Although reversible acute tubular dysfunction is well recognised with ifosfamide therapy, the long-term outc ome of ifosfamide-induced renal injury remains unclear. The results of the current study suggest that ifosfamide can cause severe irreversible renal t ubulointerstitial injury and should be used with caution even when there is initially normal renal function.