Prognosis of extrahepatic bile-duct atresia after hepatoportoenterostomy

Clinical and histologic findings from 206 patients operated upon for extrah epatic biliary atresia (EHBA) are analyzed in order to define the prognosis of patients with EHBA. The prospective study took into consideration both initial fibrosis of the liver and the morphology of the porta hepatis (PH) at surgery. Kaplan-Meier survival estimates and statistical calculations de monstrated a relationship between long-term survival and histologic finding s in the liver and porta hepatis. The efficacy of HPE is significantly infl uenced by the morphology of the PH and to a lesser extent by the initial li ver fibrosis. Surgery should thus achieve pattern I morphology of the PH, b ut this is problematic because of the close relationship of the vascular an d biliary structures in its two lateral zones.