This paper concerns the scale-up precision synthesis of octa-arm polyisobut
ylene (PIB) stars. Specifically, we have optimized to the 100-200 g scale t
he preparation of star polymers consisting of eight PIE arms radiating from
a calix[8]arene core. The synthesis strategy involved the use of a calix[8
]arene fitted with eight p-C(CH3)(2)OCH3 groups as the initiator in conjunc
tion with mixed BCl3/TiCl4 coinitiators in hexanes/methyl chloride solvent
systems at - 80 degrees C. Various possible side-reactions have been identi
fied and means for their suppression/elimination were developed.