R. Torp et al., Ultrastructural analyses of beta-amyloid in the aged dog brain: Neuronal beta-amyloid is localized to the plasma membrane, PROG NEUR-P, 24(5), 2000, pp. 801-810
Citations number
16
Categorie Soggetti
Neurosciences & Behavoir
Journal title
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
1. An electron microscopic study was undertaken to study beta-amyloid (A be
ta) deposition and neuropathology in aged dogs.
2. A positive correlation between A beta deposits and neuropathology was fo
und in some dogs. Massive A beta deposition was correlated to advanced lesi
ons.
3. By use of immunocytochemistry A beta fibers were identified within plaqu
es, around vessels and in association with cell membranes.