Event-related potentials were recorded from 11 subjects after ingesting caf
feine (250 mg) or placebo. Subjects were instructed to attend selectively t
o stimuli with a specified color (red or blue) in order to react to the occ
urrence of a target within the attended category. Reaction times revealed f
aster responses for the caffeine condition, whereas no differences in strat
egy were observed. Color attention effects were identified as frontal selec
tion positivity, occipital selection negativity, and N2b, whereas target de
tection was reflected in P3b. Effects of treatment were found as a more pos
itive-going frontal P2 component in the caffeine condition. In addition, an
interaction between attention and treatment could be observed on the N2b c
omponent. This pattern of results suggests that caffeine yields a higher ov
erall arousal level, more profound processing of both attended and unattend
ed information. and an acceleration of motor processes.