KAPOSI DISEASE

Viral origin: DNA sequences related to herpes gamma virus have been ob served in Kaposi disease lesions in HIV-positive patients independent of their sex, age or geographical origin. This novel viral agent has b een named KSHV (Kaposi sarcoma associated herpes virus) or more approp riately HHVI (human herpes virus type 8). HHV8-associated diseases: In addition to Kaposi disease, HHVB has been found in association with o ther diseases such as B-cell serous tissue lymphomas in HIV+ and HIV- subjects and Castleman's disease, pseudolymphoma epidemiologically ass ociated with development of Kaposi disease. Perspectives: Certain anti viral treatments have been proposed. Animal models will beuseful for a n experimental verification of the possible oncogenic potiential of HH V8.