We report three cases of compartment syndrome in the thigh related to drug
intoxications. Compartment syndrome is an uncommon condition often diagnose
d late as it may occur in unconscious patients. The typical clinical presen
tation begins with pain of the lower limb refractory to major antagesics. T
he condition then progresses with sensoromotor involvement of the sciatic n
erve, Rapid onset of acute renal failure in the setting of a crush syndrome
may be life-threatening with a long-term risk of major sensoromotor sequel
ae. Surgical treatment with aponeurotomy is required rapidly to limit seque
lae.