The chemical reactivity of beta-lactams, beta-sultams and beta-phospholactams

Authors
Page, MI Laws, AP
Citation
Mi. Page et Ap. Laws, The chemical reactivity of beta-lactams, beta-sultams and beta-phospholactams, TETRAHEDRON, 56(31), 2000, pp. 5631-5638
Citations number
80
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
56
Issue
31
Year of publication
2000
Pages
5631 - 5638
Database
ISI
SICI code
0040-4020(20000728)56:31<5631:TCROBB>2.0.ZU;2-M
Abstract
beta-Lactam antibiotics display a range of biological activities. The origi n of this diverse biological activity is discussed with reference to the ch emical reactivity of the small ring system. The reactions of beta-sultams a nd beta-phospholactams with simple nucleophiles are reported and their pote ntial as mechanism based inhibitors of bacterial and mammalian serine prote ases is described. (C) 2000 Elsevier Science Ltd. All rights reserved.