Citation
A. Bulychev et al., N-sulfonyloxy-beta-lactam inhibitors for beta-lactamases, TETRAHEDRON, 56(31), 2000, pp. 5719-5728
Citations number
37
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020
→ ACNP
Volume
56
Issue
31
Year of publication
2000
Pages
5719 - 5728
Database
ISI
SICI code
0040-4020(20000728)56:31<5719:NIFB>2.0.ZU;2-S
Abstract
Structure-function analysis with a series of N-sulfonyloxy beta-lactam mole
cules as inhibitors of beta-lactamases is reported. The best of these compo
unds acylate the active site of the class A TEM-1 beta-lactamase from Esche
richia coli rapidly, and resist deacylation. Whereas acylation of the activ
e site of the class C beta-lactamase from Enterobacter cloacae was not seen
, these compounds function as competitive inhibitors of this enzyme. (C) 20
00 Elsevier Science Ltd. All rights reserved.