Citation
Rc. Wilmouth et al., Reaction of clavams with elastase reveals a general method for inhibiting 'serine' enzymes, TETRAHEDRON, 56(31), 2000, pp. 5729-5733
Citations number
27
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020
→ ACNP
Volume
56
Issue
31
Year of publication
2000
Pages
5729 - 5733
Database
ISI
SICI code
0040-4020(20000728)56:31<5729:ROCWER>2.0.ZU;2-X
Abstract
Ester derivatives of clavulanic acid acylate Ser-195 of the serine protease
porcine pancreatic elastase to form stable malonyl semi-aldehyde derivativ
es, analogous to those formed in the inhibition of beta-lactamases by clavu
lanic acid itself. Formation of such derivatives maybe a general way of inh
ibiting 'serine' enzymes. (C) 2000 Elsevier Science Ltd. All rights reserve
d.