Iris indocyanine green angiography in pseudoexfoliation syndrome and capsular glaucoma

Purpose: The iris vasculature shows typical changes in pseudoexfoliation sy ndrome (PXS) revealed by iris fluorescein angiography (IFA), such as hypope rfusion, microneovascularisation, and anastomotic vessels, Iris indocyanine green angiography (IICGA) can visualize more precisely details of the iris vascular pattern, especially as regards hypoperfusion and capillary dilata tions, The aim of the present study is to describe the angiographic feature s of PXS on IFA and IICGA, comparing eyes affected with those not affected by capsular glaucoma, Methods: In a prospective study 42 consecutive patients affected by PXS und erwent a complete ophthalmologic examination including LFA and IICGA, Thirt y-two eyes were affected by capsular glaucoma. IICGA was performed using IM AGEnet System H1024, Results: IFA can easily detect the microneovascularisation, whereas IICGA a llows a better recognition of iris hypoperfusion and anastomotic vessels, a nd it can reveal iris pigment epithelium defects. While the degree of hypop erfusion was similar in the two subgroups, eyes affected by capsular glauco ma more frequently showed signs of both microneovascularisation (marked str omal tufts and marked plexi), and of anastomotic vessels (peripheral loop, lesser circle and oblique vessels), with statistically significant differen ce. A clear correlation between hypoperfusion, microneovascularisation, and anastomotic vessels as regards site and extent was not noticed. Conclusions: A different angiographic pattern can be detected in PXS eyes w ith capsular glaucoma in comparison with eyes without it. Further studies a re needed to correlate angiographic features revealed by IFA and IICGA, wit h clinical features.