Choroideremia associated with subretinal neovascular membrane

Purpose: To report two Japanese patients with choroideremia, one male and o ne heterozygous female, who developed subretinal neovascular membrane and/o r subretinal fibrosis in the intermediate stage of the disease, and, in add ition, to describe marked clinical manifestation in a heterozygous carrier female, Method: Two patients were examined by slip-lamp biomicroscopy, ophthalmosco py and other ophthalmoloscopic examinations. Results: Two cases showed moderately advanced ophthalmoscopic and functiona l abnormalitities compatible with choroideremia, and in addition, subretina l lesion in the fovea and/or midperiphery, Conclusion: The intermediate stage of choroideremia may occasionally be com plicated with choroidal neovascular membrane in the fovea, the midperiphery , or both, which resolves spontaneously and results in subretinal fibrous s carring, The occurrence of this complication in the fovea leads to episodic central visual loss, while midperipheral lesion may remain unrecognized.