Thermo-reversible self-assembly of nanoparticles derived from elastin-mimetic polypeptides

Authors
Lee, TAT Cooper, A Apkarian, RP Conticello, VP
Citation
Tat. Lee et al., Thermo-reversible self-assembly of nanoparticles derived from elastin-mimetic polypeptides, ADVAN MATER, 12(15), 2000, pp. 1105
Citations number
25
Categorie Soggetti
Multidisciplinary,"Material Science & Engineering
Journal title
ADVANCED MATERIALS
ISSN journal
09359648 → ACNP
Volume
12
Issue
15
Year of publication
2000
Database
ISI
SICI code
0935-9648(20000802)12:15<1105:TSONDF>2.0.ZU;2-9
Abstract
Large protein-based micellar aggegrates (see figure) are reversibly formed upon self-assembly of the amphiphilic diblock copolymer-based on elastin-mi metic peptide sequences-biosynthesized here. The biocompatibility, high rec ombinant protein yields, physiological stability, and tunable responsive pr operties of these polymers make them attractive candi- dates for controlled delivery and release applications.