Sublingual allergen immunotherapy: estimation of efficacy

Efficacy of sublingual immunotherapy has been investigated in several studi es. A review of the literature yielded 21 controlled studies, of which 14 w ere thought to have a comparable design, in evaluating the efficacy of veru m vs. placebo. In 13 of these 14 studies, sublingual immunotherapy was show n to be effective, in reducing symptoms and/or medication needs. In spite o f this overall positive valuation, the results are not homogeneous and shou ld lead to further investigation.