Brimonidine 0.2% versus dorzolamide 2% each given three times daily to reduce intraocular pressure

PURPOSE: To evaluate the efficacy and safety of brimonidine compared with d orzolamide given three times daily as monotherapy in patients with primary open-angle glaucoma or ocular hypertension, METHODS: In a double-masked, multicenter, crossover comparison in 40 patien ts, qualified patients were washed out from their previous medication and r andomized to dorzolamide 2% or brimonidine 0.2% for the first 6-week treatm ent period. Patients then were washed out for 2 weeks and started on the op posite medication for the second 6-week period. RESULTS: Baseline intraocular pressure for ail 40 subjects (76 eyes) was 24 .1 +/- 2.0 mm Hg. This study found that the 8:00 AM trough intraocular pres sure after 6 weeks of therapy for dorzolamide was 20.7 +/- 3.1 mm Hg and fo r brimonidine 20.8 +/- 3.2 mm Hg (P = .99). The peak intraocular pressure ( 2 hours after dosing) for dorzolamide was 18.6 +/- 3.4 mm Hg: and for brimo nidine 17.8 +/- 2.7 mm Hg (P = .10). Dorzolamide caused more stinging upon instillation (P < .01) and brimonidine more itching (P = .01). No statistic al differences existed between groups for systemic adverse events. Six pati ents, all on brimonidine, were discontinued from a treatment period early. Of these, two were discontinued for inadequate pressure control, two with d izziness and fatigue, one with ocular pain, and one for lifestyle reasons ( P = .07). CONCLUSIONS: This study found similar efficacy and safety between monothera py treatment with dorzolamide or brimonidine when each was given three rime s daily to patients with ocular hypertension or primary open-angle glaucoma . (C) 2000 by Elsevier Science Inc, Ail rights reserved.