Sensitivity of cyclin E-overexpressing cells to cisplatin/taxol combinations

Authors
Citation
Ml. Smith et Yr. Seo, Sensitivity of cyclin E-overexpressing cells to cisplatin/taxol combinations, ANTICANC R, 20(4), 2000, pp. 2537-2539
Citations number
28
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
ANTICANCER RESEARCH
ISSN journal
02507005 → ACNP
Volume
20
Issue
4
Year of publication
2000
Pages
2537 - 2539
Database
ISI
SICI code
0250-7005(200007/08)20:4<2537:SOCECT>2.0.ZU;2-Z
Abstract
Combinations of anticancer drugs, referred to as "combinatorial" chemothera py, is often used in the treatment of cancer patients. Recent advances in o ra understanding of cell cycle and cellular stress responses may be viewed in the context of responses to anticancer drugs. A desired outcome irs cell death preferentially occurring in cancer cells. We report that cyclin E, a n oncogene that is deregulated in breast and other human cancers can sensit ise cancer cells to cisplatin/taxol combinations. The drug combination may selectively induce apoptosis in cyclin E-overexpressing cells.