Sensitivity of cyclin E-overexpressing cells to cisplatin/taxol combinations

Combinations of anticancer drugs, referred to as "combinatorial" chemothera py, is often used in the treatment of cancer patients. Recent advances in o ra understanding of cell cycle and cellular stress responses may be viewed in the context of responses to anticancer drugs. A desired outcome irs cell death preferentially occurring in cancer cells. We report that cyclin E, a n oncogene that is deregulated in breast and other human cancers can sensit ise cancer cells to cisplatin/taxol combinations. The drug combination may selectively induce apoptosis in cyclin E-overexpressing cells.