Purpose: To examine the management and possible causes of primary valv
e malfunction of the Krupin eye valve with disk. Methods: The authors
reviewed the results of 113 patients undergoing implantation of the Kr
upin eye valve with disk and identified eight patients with primary va
lve malfunction requiring surgical revision. Results: Valve revision i
nvolved manipulation (n = 1 case), explantation of the malfunctioning
valve and implantation of a new valve (n = 2), and amputation of the v
alve (n = 5). Six of eight patients had final intraocular pressures of
<21 mmHg on one or no medications at a mean interval of 15.9 months (
range 5-36) after surgical revision. Transient postoperative hypotony
was noted in three patients and chronic hypotony with loss of light pe
rception in one patient. One explanted valve was examined and found to
have partially fused leaflets.Conclusions: Surgical revision in cases
of primary valve malfunction of the Krupin eye valve with disk may be
accomplished relatively safely with an acceptable level of postoperat
ive complications. ?he etiology of primary valve malfunction may be re
lated to the sterilization process and prolonged storage before implan
tation.