A comparative study of genotoxic effects in the treatment of trichomonas vaginalis infection: metronidazole or nalidixic acid

We performed a prospective randomized study to compare the potential genoto xic effects of metronidazole and nalidixic acid which they are used in the treatment of Trichomonas vaginalis infection. 20 patients with Trichomonas vaginalis infections participated in this study. 14 patients with vaginal t richomoniasis were treated with therapeutic doses of metronidazole 250 mg 3 times/d and six patients were treated with nalidixic acid 400 mg twice a d ay for 10 d. The genotoxic potential of a variety of mutagenic and carcinog enic agents can be evaluated by sister-chromatid exchange (SCE) test as a r apid cytogenetic test. An increased number of exchanges in lymphocytes refl ects the influence of mutagens. No significant difference was observed in t he SCE frequency of metronidazole treated patient however, a statistically significant increase (P<0.05) after nalidixic acid treatment could be descr ibed. We conclude that in spite of wide use of nalidixic acid for Trichomon as vaginalis infection, because of its potential genotoxic effect its usage must be individualized especially for pregnant women and small babies.