New diaminoether coumarinic derivatives with anti-inflammatory activity

Four coumarinyl-oxy-diamines were synthesized and tested as anti-inflammato ry agents, pKa and log P were theoretically calculated. These compounds wer e tested for their ability to interact with 1,1 -diphenyl-2-picrylhydrazyl stable free radical (DPPH), to inhibit proteolysis and soybean lipoxygenase (LOX) in vitro. They were found to inhibit proteolysis (82-90 %) and soybe an lipoxygenase activity (52-79 %) very significant. On the contrary, their reducing ability was found to be low (8-22 %). The effect of the synthesis ed compounds on inflammation using the carageenan-induced rat paw oedema mo del was studied. They showed a potent inhibitory effect on inflammation (37 -55 %). Both anti-inflammatory and antioxidant activities depended on some structural characteristics of the synthesised compounds.